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DCVC

Catalog No. T36401 CAS 13419-46-0

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

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DCVC, CAS 13419-46-0

Pack Size	Availability	Price/USD
2 mg	5 days	$ 275.00
5 mg	5 days	$ 347.00
10 mg	5 days	$ 541.00
1 mL * 10 mM (in DMSO)	5 days	$ 382.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

In vitro

In vitro, DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.

Molecular Weight	216.09
Formula	C5H7Cl2NO2S
CAS No.	13419-46-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (106.44 mM)

H2O: 1.034 mg/mL (4.79 mM)

References and Literature

1. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. 2. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. 3. Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49.

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Keywords

DCVC 13419-46-0 inhibitor inhibit

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