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YM-53601 free base

Catalog No. T13371   CAS 182959-28-0

YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.

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YM-53601 free base Chemical Structure
YM-53601 free base, CAS 182959-28-0
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
In vivo In the plasma of rats, YM-53601 inhibits cholesterol biosynthesis from acetate in a dose-dependent manner. YM-53601 inhibits both FFA and triglyceride biosynthesis in rats treated with cholestyramine over the same dose range at which it inhibits cholesterol biosynthesis. Through a single oral administration, YM-53601 reduces the increase in plasma triglyceride levels of hamsters induced by protamine sulfate injection, thereby inhibiting lipoprotein lipase (LPL), thereby increasing plasma very low density lipoprotein (VLDL) Triglyceride levels. YM-53601 can also reduce plasma triglyceride and cholesterol levels in hamsters treated with Triton WR1339, which also inhibits the degradation of VLDL. Plasma cholesterol was significantly decreased as soon as 1 h after single administration of YM-53601 in hamsters fed a normal diet.
Molecular Weight 336.4
Formula C21H21FN2O
CAS No. 182959-28-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ugawa T, et al. YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents. Br J Pharmacol. 2003 May;139(1):140-6.

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Keywords

YM-53601 free base 182959-28-0 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK YM53601 YM53601 free base YM 53601 YM 53601 free base YM-53601 inhibitor inhibit

 

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