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XMU-MP-1

XMU-MP-1
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Purity:99.68%
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XMU-MP-1

Catalog No. T4212Cas No. 2061980-01-4
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$48In Stock
2 mg$72In Stock
5 mg$98In Stock
10 mg$155In Stock
25 mg$322In Stock
50 mg$538In Stock
100 mg$778In Stock
1 mL x 10 mM (in DMSO)$96In Stock
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Product Introduction

Bioactivity
Description
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
In vitro
XMU-MP-1 effectively reduces the phosphorylation of MOB1, LATS1/2, and YAP in HepG2 cells in a concentration-dependent manner, with effective doses ranging from 0.1 to 10 μM. It also inhibits MOB1 phosphorylation induced by hydrogen peroxide and prevents MST1/2 autophosphorylation across various cell lines, including mouse macrophage-like cells, human osteosarcoma, and human colorectal adenocarcinoma cells. By blocking MST1/2 kinase activities, XMU-MP-1 activates the downstream effector, Yes-associated protein (YAP), thereby promoting cell growth. Its action potently and reversibly suppresses the activities of MST1/2 kinases, enhancing YAP activation in cells.
In vivo
XMU-MP-1 displays excellent in in vivo pharmacokinetics and is able to augment mouse intestinal repair, as well as liver repair and regeneration, in both acute and chronic liver injury mouse models at a dose of 1 to 3 mg/kg via intraperitoneal injection. XMU-MP-1 treatment exhibited substantially greater repopulation rate of human hepatocytes in the Fah-deficient mouse model than in the vehicle-treated control, indicating that XMU-MP-1 treatment might facilitate human liver regeneration. Thus, the pharmacological modulation of MST1/2 kinase activities provides a novel approach to potentiate tissue repair and regeneration, with XMU-MP-1 as the first lead for the development of targeted regenerative therapeutics.
Kinase Assay
XMU-MP-1 is dissolved in DMSO (stock concentration, 10 mM). For the in vitro kinase inhibition assays, recombinant GST-tagged MOB1a and various forms of recombinant His-tagged full-length MST1 or MST2 kinase are expressed and purified from Escherichia coli. The assays are performed with the various doses of XMU-MP-1 in the kinase assay buffer for 30 min at 30°C[1].
Chemical Properties
Molecular Weight416.48
FormulaC17H16N6O3S2
Cas No.2061980-01-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 12.5 mg/mL (30.01 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4011 mL12.0054 mL24.0108 mL120.0538 mL
5 mM0.4802 mL2.4011 mL4.8022 mL24.0108 mL
10 mM0.2401 mL1.2005 mL2.4011 mL12.0054 mL
20 mM0.1201 mL0.6003 mL1.2005 mL6.0027 mL

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