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WCK-5153

Catalog No. T23858 CAS 1436862-38-2

Synonyms: WCK 5153, WCK5153

WCK-5153 is an enhancer of β-Lactamase and an inhibitor of PBP2 with antimicrobial activities against Pseudomonas aeruginosa. WCK-5153 can be used in studies about the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

WCK-5153, CAS 1436862-38-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 333.00
10 mg	In stock	$ 477.00
25 mg	In stock	$ 782.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,470.00
500 mg	In stock	$ 2,950.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 98.12%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	WCK 5153, WCK5153
Molecular Weight	377.37
Formula	C12H19N5O7S
CAS No.	1436862-38-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.77 mg/mL (10 mM)

References and Literature

1. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6):e02529-16. 2. Papp-Wallace KM, et al. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086. 3. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02529-16. 4. Moya B, et al. In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-β-Lactamase-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e00128-19.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Bacterial Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Ceforanide Cephapirin Sodium Sulfamethazine Dup-721 AU1235 Sanguisorbigenin Bestatin Carbenicillin disodium

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WCK-5153 1436862-38-2 Microbiology/Virology Antibacterial WCK 5153 WCK5153 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.