Anti-Gram-Negative Bacterial Library

Catalog No. L4521

Gram-negative bacteria are a class of bacteria that appear red or pink in Gram staining. They possess a complex cell structure characterized by a thin peptidoglycan layer and a crucial outer membrane. This outer membrane contains lipopolysaccharides (LPS, also known as endotoxins), which not only enhance their environmental adaptability but also significantly contribute to their intrinsic resistance to antibiotics. Common pathogenic Gram-negative bacteria include Escherichia coli, Helicobacter pylori, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella spp. These pathogens are major causes of urinary tract infections, gastric cancer, pneumonia, intra-abdominal infections, and hospital-acquired infections.
In recent years, the rapid spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria has become a major challenge in clinical treatment. Particularly concerning are strains that produce extended-spectrum β-lactamases (ESBLs) and carbapenemases (such as NDM and KPC), which confer resistance to a broad range of β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. These strains often also show cross-resistance to aminoglycosides and fluoroquinolones, leaving very limited treatment options and highlighting the urgent need for the development of novel and effective antimicrobial agents.
TargetMol’s Anti-Gram-Negative Bacteria Compound Library includes 240 small molecules with activity against Gram-negative bacteria. It serves as a powerful tool for antibacterial drug research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.