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Valnemulin hydrochloride

Catalog No. T6715 CAS 133868-46-9

Synonyms: Valnemulin HCl

Valnemulin hydrochloride (Valnemulin HCl) is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.

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Valnemulin hydrochloride Chemical Structure

Valnemulin hydrochloride, CAS 133868-46-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 61.00
100 mg	In stock	$ 98.00
200 mg	In stock	$ 143.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Valnemulin hydrochloride (Valnemulin HCl) is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.
In vitro	Valnemulin (20 μM) completely inhibits the peptidyl transferase reaction, thus inhibits peptide bond formation. Valnemulin enhances the reactivity of nucleotides A2058 and A2059 moderately, whereas they protect U2506 strongly. [1] Valnemulin shows exceptional activity against M hyopneumoniae (MIC90 0.5 μg/mL) and M hyosynoviae (MIC range 0.1-0.25 0.5 μg/mL) field strains. [2] Valnemulin is mainly active against Gram-positive bacteria with moderate activity against some fastidious Gram-negative bacilli (e.g., anaerobic bacteria) and Mycoplasma and is used almost exclusively in animals, largely in swine in China. [3]
In vivo	Valnemulin is absorbed rapidly, distributed widely and rapidly and excreted rapidly after oral administration to rats. [3] Valnemulin results in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss in young calves. Valnemulin results in a more rapid reduction of clinical scores and eliminated M. bovis from the lungs more effectively than Enrofloxacin. [4] Valnemulin significantly decreases the wet-to-dry weight (W/D) ratios of lungs, protein concentrations, and the number of total cells, neutrophils, macrophages, and leukomonocytes, and histologic analysis indicates that valnemulin significantly attenuates tissue injury. Valnemulin significantly increases LPS-induced SOD activity in BALF and decreases lung myeloperoxidase (MPO) activity activity as well. Valnemulin also inhibits the production of tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, which is consistent with mRNA expression in lung. [5]

Synonyms	Valnemulin HCl
Molecular Weight	601.28
Formula	C31H52N2O5S·HCl
CAS No.	133868-46-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 92 mg/mL (153 mM)

DMSO: 93 mg/mL (154.7 mM)

Ethanol: 93 mg/mL (154.7 mM)

References and Literature

1. Poulsen SM, et al. Mol Microbiol, 2001, 41(5), 1091-1099. 2. Hannan PC, et al. Res Vet Sci, 1997, 63(2), 157-160. 3. Yuan LG, et al. J Vet Pharmacol Ther, 2011, 34(3), 224-231. 4. Stipkovits L, et al. Res Vet Sci, 2005, 78(3), 207-215.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Infection Compound Library Bioactive Compounds Library Max Anti-Bacterial Compound Library NO PAINS Compound Library Macrocyclic Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Antibiotics Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Valnemulin hydrochloride 133868-46-9 Microbiology/Virology Others Antibacterial Antibiotic inhibit Valnemulin Inhibitor Bacterial Valnemulin HCl Valnemulin Hydrochloride inhibitor

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