Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Timegadine is a competitive inhibitor of <a href="/target/COX" style="display: inline; color: #c13a36">COX</a> and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for <a href="/target/COX" style="display: inline; color: #c13a36">COX</a> and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 970.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets. |
Targets&IC50 | COX:20 μM (in rat brain), COX:5 nM (in rabbit platelets), lipo-oxygenase:100 μM (in horse washed rabbit platelets) |
In vitro | Timegadine is a potent, competitive COX and lipo-oxygenase inhibitor, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets[2],and is a new antiinflammatory agent, |
In vivo | Timegadine is a potent, competitive prostaglandin synthetase inhibitor which also inhibits cyclo-oxygenase (COX) and lipoxygenase. Daily oral doses of 10 to 30 mg/kg of Timegadine significantly inhibit both the primary and secondary lesions of adjuvant arthritis when the treatment is initiated on the day of the disease induction and continues for 28 days. Timegadine is able specifically to prevent the development of the swelling of the non-injected paw until 28 days after the adjuvant injection when administered for 5 days prior to and 5 days after the induction of the disease, in analogy with the effect of cyclophosphamide[1].Timegadine is a new antiinflammatory agent, |
Synonyms | SR1368 |
Molecular Weight | 365.5 |
Formula | C20H23N5S |
CAS No. | 71079-19-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Timegadine 71079-19-1 Immunology/Inflammation Neuroscience COX SR1368 Inhibitor inhibitor inhibit