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Tenovin-D3

Catalog No. T26259 CAS 1258283-70-3

Synonyms: TenovinD3

Tenovin-D3 is a Sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tenovin-D3, CAS 1258283-70-3

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 970.00 $ 776.00
50 mg	6-8 weeks	$ 1,980.00 $ 1,584.00
100 mg	6-8 weeks	$ 2,500.00 $ 2,000.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.

Synonyms	TenovinD3
Molecular Weight	533.9
Formula	C22H27Cl3N4O3S
CAS No.	1258283-70-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liu R, Dang W, Du Y, Zhou Q, Jiao K, Liu Z. SIRT2 is involved in the modulation of depressive behaviors. Sci Rep. 2015 Feb 12;5:8415. doi: 10.1038/srep08415. PubMed PMID: 25672834; PubMed Central PMCID: PMC4325337. 2. McCarthy AR, Sachweh MC, Higgins M, Campbell J, Drummond CJ, van Leeuwen IM, Pirrie L, Ladds MJ, Westwood NJ, Laín S. Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner. Mol Cancer Ther. 2013 Apr;12(4):352-60. doi: 10.1158/1535-7163.MCT-12-0900. Epub 2013 Jan 15. PubMed PMID: 23322738.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tenovin-D3 1258283-70-3 TenovinD3 Tenovin D3 Tenovin-D-3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.