Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TES-1025 is an effective and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (IC50: 13 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 58.00 | |
10 mg | In stock | $ 79.00 | |
25 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 174.00 | |
100 mg | In stock | $ 254.00 |
Description | TES-1025 is an effective and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (IC50: 13 nM). |
Targets&IC50 | ACMSD (human):13±3 nM |
In vitro | TES-1025 increases NAD+ levels in cellular systems[1]. |
In vivo | TES-1025 (0.5 mg/kg; i.v.) shows low blood clearance, with low volumes of distribution and half-lives of about 5.33 h, although the blood concentration of TES-1025 (5 mg/kg) is quantifiable for up to 8 h after oral administration. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h. The greater oral exposure of TES-1025 is AUC0-8h of 19 200 h•ng/mL and 36 600 h•ng/mL, respectively[1]. |
Molecular Weight | 383.44 |
Formula | C18H13N3O3S2 |
CAS No. | 1883602-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (247.76 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TES-1025 1883602-21-8 Others TES 1025 inhibit Inhibitor TES1025 inhibitor