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Speract

Catalog No. T7487 CAS 76901-59-2

Speract is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm Mitochondrial Metabolism.

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Speract, CAS 76901-59-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Speract is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.

In vitro

The stimulation of sperm with speract depolarizes the mitochondrion and increases the levels of NADH.?Surprisingly, these responses are independent of external Ca(2+) and are due to the increase in intracellular pH (pHi) induced by speract.?Speract, by regulating pHi, in addition to [Ca(2+)]i, may finely modulate mitochondrial metabolism to control motility and ensure that sperm reach the egg and fertilize it[1].

Molecular Weight	891.93
Formula	C38H57N11O14
CAS No.	76901-59-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Darszon, Alberto, Garcia-Rincon, et al. Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism[J]. Biochimica Et Biophysica Acta Bioenergetics, 2016. 1. García-Rincón J, et al. Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. Biochim Biophys Acta. 2016 Apr;1857(4):415-26. 2. Hansbrough J . Speract: Purification and characterization of a peptide associated with egg that activates spermatozoa[J]. J Biol Chem, 1981, 256(3):1447-1452.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Speract 76901-59-2 Metabolism Others Mitochondrial Metabolism inhibit Inhibitor inhibitor

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