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SR31527

Catalog No. T28848 CAS 311814-78-5

Synonyms: SR-31527, SR31527 chloride, SR 31527

SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.

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SR31527, CAS 311814-78-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,350.00
50 mg	6-8 weeks	$ 1,760.00
100 mg	6-8 weeks	$ 2,720.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 439.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.
Targets&IC50	KIFC1:6.6 µM, KIFC1:25.4 nM(Kd)
In vitro	SR31527 (50 µ M ; 24h) induced the formation of multiple Spindle apparatus in MDA-MB-231, BT549 and MDA-MB-435s cells.[1] SR31527 (0-100 µ M ; 96 hours, 10-12 days) reduces the cell viability and colony formation of breast cancer cells, and is less cytotoxic to LL47 cells.[1]

Synonyms	SR-31527, SR31527 chloride, SR 31527
Molecular Weight	319.81
Formula	C15H14ClN3OS
CAS No.	311814-78-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.2 mg/mL (10 mM)

References and Literature

1. Zhang W, et al. Discovery of a novel inhibitor of kinesin-like protein KIFCBiochem J. 2016 ; 473(8):1027-1035. 2. Yukawa M, et al. Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors. Fungal Genet Biol. 2018 ; 116:33-41.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SR31527 311814-78-5 Cytoskeletal Signaling Kinesin SR-31527 Chloride SR-31527 SR31527 Chloride SR31527 chloride SR 31527 SR 31527 Chloride inhibitor inhibit

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