Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. |
Targets&IC50 | MC-4 receptor (function):11 nM , MC-4 receptor (binding):22 nM |
In vitro | SNT207858 demonstrates binding to the MC-4 receptor at an affinity of 22 nM, exhibiting significant specificity with a 170-fold greater selectivity when compared to MC-3, and a 40-fold increased selectivity relative to MC-5. |
In vivo | In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days). |
Molecular Weight | 689.54 |
Formula | C32H45Cl4N5O3 |
CAS No. | 1104080-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SNT-207858 1104080-42-3 Others SNT207858 SNT 207858 inhibitor inhibit