Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 81.00 | |
5 mg | In stock | $ 327.00 | |
10 mg | In stock | $ 492.00 | |
25 mg | In stock | $ 787.00 | |
50 mg | In stock | $ 1,120.00 | |
100 mg | In stock | $ 1,490.00 |
Description | SN50 acetate is a cell permeable inhibitor of NF-κB translocation. |
In vitro | Pretreatment with SN50 acetate results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups[1]. Topical SN50 acetate suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls[2]. Treating the human gastric cancer cells SGC7901 with SN50 acetate could significantly enhance the effects of LY294002 on inducing cell death after 24 h[3]. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury[4]. |
In vivo | Treatment with SN50 acetate accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 acetate pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 acetate results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI[1]. |
Molecular Weight | 2841.55 |
Formula | C131H234N36O31S |
CAS No. | T12942L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SN50 acetate (213546-53-3 free base) T12942L NF-Κb NF-κB SN50 Acetate SN50 acetate (213546 53 3 free base) SN 50 Acetate SN-50 Acetate SN50 acetate (213546533 free base) SN-50 acetate (213546-53-3 free base) 213546-53-3 free base 213546-53-3 inhibitor inhibit