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SN50 acetate (213546-53-3 free base)

Catalog No. T12942L   CAS T12942L

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

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SN50 acetate (213546-53-3 free base) Chemical Structure
SN50 acetate (213546-53-3 free base), CAS T12942L
Pack Size Availability Price/USD Quantity
1 mg In stock $ 81.00
5 mg In stock $ 327.00
10 mg In stock $ 492.00
25 mg In stock $ 787.00
50 mg In stock $ 1,120.00
100 mg In stock $ 1,490.00
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Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
In vitro Pretreatment with SN50 acetate results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups[1]. Topical SN50 acetate suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls[2]. Treating the human gastric cancer cells SGC7901 with SN50 acetate could significantly enhance the effects of LY294002 on inducing cell death after 24 h[3]. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury[4].
In vivo Treatment with SN50 acetate accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 acetate pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 acetate results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI[1].
Molecular Weight 2841.55
Formula C131H234N36O31S
CAS No. T12942L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

TargetMolReferences and Literature

1. Sun Y X , Dai D K , Liu R , et al. Therapeutic effect of SN50, an inhibitor of nuclear factor-κB, in treatment of TBI in mice[J]. Neurological Sciences, 2013, 34(3):345-355. 2. Szymura S . Therapeutic Effect of Topical Administration of SN50, an Inhibitor of Nuclear Factor-κB, in Treatment of Corneal Alkali Burns in Mice[J]. American Journal of Pathology, 2005, 166(3):1393-1403. 3. Zhao K , Zhu B S , Gong W , et al. SN50 enhances the effects of LY294002 on cell death induction in gastric cancer cell line SGC7901[J]. Archives of Medical Science Ams, 2013, 9:990-998. 4. Chian C F , Chiang C H , Chuang C H , et al. Inhibitor of nuclear factor-κB, SN50, attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model[J]. Translational Research, 2014, 163(3):211-220.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Antidepressant Compound Library NO PAINS Compound Library Oxidation-Reduction Compound Library

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NF-κΒ activator 1 Sanggenon C Aucubin Demethyleneberberine Rocaglamide 1-Caffeoylquinic acid GGTI 2147 Ginsenoside Rk3

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Keywords

SN50 acetate (213546-53-3 free base) T12942L NF-Κb NF-κB SN50 Acetate SN50 acetate (213546 53 3 free base) SN 50 Acetate SN-50 Acetate SN50 acetate (213546533 free base) SN-50 acetate (213546-53-3 free base) 213546-53-3 free base 213546-53-3 inhibitor inhibit

 

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