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S55746 hydrochloride

Catalog No. T12824   CAS 1448525-91-4
Synonyms: BLC201 (hydrochloride)

S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.

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S55746 hydrochloride Chemical Structure
S55746 hydrochloride, CAS 1448525-91-4
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 632.00
50 mg 10-14 weeks $ 822.00
100 mg 10-14 weeks $ 1,410.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
Targets&IC50 Bcl-xL:186 nM (kd)(ki), Bcl-xL:520 nM (ki), Bcl-2:1.3 nM (ki), Bcl-2:3.9 nM (kd)
In vitro S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death.
In vivo S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active inhibitor of BCL-2 . In RS4, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth;11 and Toledo models time- and dose-dependently.
Synonyms BLC201 (hydrochloride)
Molecular Weight 747.28
Formula C43H43ClN4O6
CAS No. 1448525-91-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088.

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Keywords

S55746 hydrochloride 1448525-91-4 Apoptosis BCL S-55746 Hydrochloride BLC 201 BLC201 S55746 Hydrochloride BLC-201 S 55746 Hydrochloride S-55746 hydrochloride BLC201 (hydrochloride) inhibitor inhibit

 

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