Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 632.00 | |
50 mg | 10-14 weeks | $ 822.00 | |
100 mg | 10-14 weeks | $ 1,410.00 |
Description | S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. |
Targets&IC50 | Bcl-xL:186 nM (kd)(ki), Bcl-xL:520 nM (ki), Bcl-2:1.3 nM (ki), Bcl-2:3.9 nM (kd) |
In vitro | S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death. |
In vivo | S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active inhibitor of BCL-2 . In RS4, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth;11 and Toledo models time- and dose-dependently. |
Synonyms | BLC201 (hydrochloride) |
Molecular Weight | 747.28 |
Formula | C43H43ClN4O6 |
CAS No. | 1448525-91-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S55746 hydrochloride 1448525-91-4 Apoptosis BCL S-55746 Hydrochloride BLC 201 BLC201 S55746 Hydrochloride BLC-201 S 55746 Hydrochloride S-55746 hydrochloride BLC201 (hydrochloride) inhibitor inhibit