Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ). |
Targets&IC50 | CaMK IIγ:30 μM, CaMK IIα:1 μM |
In vitro | Higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098). Rimacalib improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause [1]. |
Synonyms | SMP 114 |
Molecular Weight | 394.44 |
Formula | C22H23FN4O2 |
CAS No. | 215174-50-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (316.90 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rimacalib 215174-50-8 Neuroscience CaMK SMP 114 SMP-114 SMP114 inhibitor inhibit