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PF 429242

Catalog No. T4317   CAS 947303-87-9

PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).

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PF 429242 Chemical Structure
PF 429242, CAS 947303-87-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 37.00
2 mg In stock $ 50.00
5 mg In stock $ 100.00
10 mg In stock $ 183.00
25 mg In stock $ 405.00
50 mg In stock $ 590.00
100 mg In stock $ 859.00
1 mL * 10 mM (in DMSO) In stock $ 100.00
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Purity: 99.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).
Targets&IC50 SREBP:0.175 μM
Molecular Weight 409.56
Formula C25H35N3O2
CAS No. 947303-87-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.1 mg/mL(50 mM)

TargetMolReferences and Literature

1. Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem.

TargetMolCitations

1. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Inhibitor Library Preclinical Compound Library Lipid Metabolism Compound Library Bioactive Compound Library Ion Channel Inhibitor Library Metabolism Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Keywords

PF 429242 947303-87-9 Membrane transporter/Ion channel Metabolism Lipid NPC1L1 PF-429242 PF429242 inhibitor inhibit

 

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