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PF 429242

Catalog No. T4317 CAS 947303-87-9

PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).

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PF 429242, CAS 947303-87-9

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Purity: 98%

Biological Description

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Description	PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).
Targets&IC50	SREBP:0.175 μM

Molecular Weight	482.49
Formula	C25H35N3O2·2HCl
CAS No.	947303-87-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 24.1 mg/mL(50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem.

Related compound libraries

This product is contained In the following compound libraries：

Preclinical Compound Library GPCR Compound Library Anti-Cancer Metabolism Compound Library Lipid Metabolism Compound Library Inhibitor Library Ion Channel Inhibitor Library Anti-Metabolism Disease Compound Library Kinase Inhibitor Library Anti-Infection Compound Library Bioactive Compound Library

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1-HEXACOSANOL FGH10019 Fatostatin hydrobromide Praeruptorin B PF 429242 Ezetimibe Ezetimibe ketone

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Keywords

PF 429242 947303-87-9 代谢离子通道 NPC1L1 Lipid Inhibitor inhibitor inhibit

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