Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,420.00 | |
50 mg | 10-14 weeks | $ 3,180.00 | |
100 mg | 10-14 weeks | $ 4,300.00 |
Description | ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity. |
Targets&IC50 | GR:(EC50)5.6 nM |
In vitro | ORIC-101 (1-1000 nM) dose-dependently decreases the expression of n GR-mediated target gene (IC50s: 17.2 and 21.2 nM, respectively). ORIC-101 displays markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1]. |
In vivo | In OVCAR5 xenograft tumor in cortisol-treated mice, ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) increases the anti-tumor activity in combination with gemcitabine and carboplatin[1]. |
Molecular Weight | 501.74 |
Formula | C34H47NO2 |
CAS No. | 2222344-98-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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ORIC-101 2222344-98-9 ORIC 101 ORIC101 inhibitor inhibit