Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,620.00 | |
50 mg | 10-14 weeks | $ 2,110.00 | |
100 mg | 10-14 weeks | $ 3,380.00 |
Description | Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property. |
In vitro | Namitecan decreases a dose-dependent decrease in EGFR expression in the different cell lines[1]. Namitecan and cetuximab cooperate in inhibiting EGFR expression. ST1968 causes a comparable level of apoptosis in A431 and A431/TPT cells (IC50: 0.21 and 0.29 μM)[2]. |
In vivo | Namitecan (10 mg/kg) combined with cetuximab (1 mg/mouse) demonstrates synergistic antitumor effects in SCC models, dependent on the EGFR gene copy number[1]. ST1968 (25 mg/kg) is associated with tolerable body weight loss and no fatal toxicity, achieving a 100% complete response rate in mice with the A431 tumor, and maintaining significant efficacy in topotecan-resistant tumors[2]. |
Synonyms | ST-1968 |
Molecular Weight | 434.44 |
Formula | C23H22N4O5 |
CAS No. | 372105-27-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Namitecan 372105-27-6 Others ST 1968 ST1968 ST-1968 inhibitor inhibit