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N-Carbethoxy-4-piperidone

Catalog No. T1340 CAS 29976-53-2

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

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N-Carbethoxy-4-piperidone Chemical Structure

N-Carbethoxy-4-piperidone, CAS 29976-53-2

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

Kinase Assay

A crude cell-free extract is isolated from LI 210 cells in culture by suspension of the cells in a given volume of 0.05mol/LTris-HCl buffer, pH 7.4, and sonic extraction with a Biosonik at 70% maximal output for 30 sec. The supernatant is collected after centrifugation at 105,000 × g for 60 min (4°C) in a Model L Spinco ultracentrifuge. The final protein concentration of the cell-free extracts is approximately 3 mg/mL. The extracts are used as the source of enzymes. Ribonucleotide reductase activity is measured. A unit of enzyme is defined as the amount that catalyzed dCMP synthesis at a rate of 1 mμmole/hr. The assay systems for the measurement of pyrimidine nucleoside (CR) and deoxynucleoside (TdR, CdR) kinases are essentially those described by Chu and Fischer. However, reactions are terminated by heating for 2 min in a boiling water bath, and the phosphorylated derivatives are isolated according to the method of Bach. Fifty-jul aliquots are applied to 1-inch discs of diethylaminoethyl paper, which are then placed in counting vials and eluted with 0.5 mL of 0.5 mol/LPCA. After 1 hr, 12 mL of Diotol are added, and the radioactivity is determined.

Molecular Weight	171.19
Formula	C8H13NO3
CAS No.	29976-53-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (350.48 mM)

References and Literature

1. Eric Gundersen et al.Bioorganic & Medicinal Chemistry Letters, 15(7), 1891-1894 (2005)

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Drug Metabolite/Impurity Library Bioactive Compounds Library Max NO PAINS Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Carbethoxy-4-piperidone 29976-53-2 Others NCarbethoxy4piperidone N Carbethoxy 4 piperidone inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.