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McMMAF

Catalog No. T16031 CAS 863971-19-1

Synonyms: Maleimidocaproyl monomethylauristatin F

McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

McMMAF, CAS 863971-19-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 672.00
100 mg	In stock	$ 956.00

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Purity: 100%

Purity: 99.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). It cannot be used as a drug itself because MMAF is highly toxic. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

Synonyms	Maleimidocaproyl monomethylauristatin F
Molecular Weight	925.16
Formula	C49H76N6O11
CAS No.	863971-19-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (108.09 mM)

References and Literature

1. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364. 2. Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library NO PAINS Compound Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

2-Methoxyestradiol Epothilone A Tirbanibulin Tubulin inhibitor 1 DM1-SMe Tubulin inhibitor 7 Sovilnesib Estramustine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

McMMAF 863971-19-1 Cytoskeletal Signaling Microtubule Associated inhibit Maleimidocaproyl monomethylauristatin F Inhibitor Drug-Linker Conjugates for ADC inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.