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MK-0343

Catalog No. T16084 CAS 233275-76-8

Synonyms: MRK-409

MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic.

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MK-0343, CAS 233275-76-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 196.00
25 mg	6-8 weeks	$ 1,100.00
50 mg	6-8 weeks	$ 1,440.00
100 mg	6-8 weeks	$ 2,180.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic.
Targets&IC50	GABAA α4 (rat):78 nM(ki), GABAA α6 (rat):980 nM(ki), GABAA α2 (rat):0.4 nM(ki), GABAA α3 (rat): 0.21 nM(ki), GABAA α5 (rat):0.23 nM(ki), GABAA α1 (rat):(ki)0.22 nM
In vivo	MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [3H]flumazenil binding assay. It has an Occ50 of 2.2?mg/kg p.o. and a corresponding plasma EC50 of 115?ng/mL .

Synonyms	MRK-409
Molecular Weight	397.38
Formula	C19H17F2N7O
CAS No.	233275-76-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Atack JR, et al. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. J Psychopharmacol. 2011 Mar;25(3):314-28.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-0343 233275-76-8 Others MRK-409 MRK 409 MRK409 MK 0343 MK0343 inhibitor inhibit

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