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Levoleucovorin

Catalog No. T32704 CAS 68538-85-2

Synonyms: LFP-754, LFP 754, Levofolene, Levofolinic acid, levo-Folinic

Levoleucovorin, as a folate analog, consists of the pharmacologically active isomer of leucovorin.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Levoleucovorin, CAS 68538-85-2

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 970.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Levoleucovorin, as a folate analog, consists of the pharmacologically active isomer of leucovorin.

Synonyms	LFP-754, LFP 754, Levofolene, Levofolinic acid, levo-Folinic
Molecular Weight	473.44
Formula	C20H23N7O7
CAS No.	68538-85-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mofidifar S, Sohraby F, Bagheri M, Aryapour H. Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study. Biogerontology. 2018 Apr;19(2):133-143. doi: 10.1007/s10522-018-9744-x. Epub 2018 Jan 15. PubMed PMID: 29335817. 2. Muto O, Munakata M, Yamagata K, Masuda A, Kotanagi K, Kichiraku T, Satoyoshi R, Kudoh K, Sawada T, Miyazawa H, Ouchi S, Kotanagi H, Sakata Y. Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation. Gan To Kagaku Ryoho. 2017 Oct;44(10):867-869. PubMed PMID: 29066681. 3. Costa T, Nuñez J, Felismino T, Boente L, Mello C. REOX: Evaluation of the Efficacy of Retreatment With an Oxaliplatin-containing Regimen in Metastatic Colorectal Cancer: A Retrospective Single-center Study. Clin Colorectal Cancer. 2017 Dec;16(4):316-323. doi: 10.1016/j.clcc.2017.03.002. Epub 2017 Mar 16. PubMed PMID: 28392022. 4. Zhao R, Aluri S, Goldman ID. The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption. Mol Aspects Med. 2017 Feb;53:57-72. doi: 10.1016/j.mam.2016.09.002. Epub 2016 Sep 21. Review. PubMed PMID: 27664775; PubMed Central PMCID: PMC5253092.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levoleucovorin 68538-85-2 LFP-754 LFP 754 Levofolene Levofolinic acid levo-Folinic inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.