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Leptomycin A

Catalog No. T11837 CAS 87081-36-5

Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.

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Leptomycin A, CAS 87081-36-5

Pack Size	Availability	Price/USD	Quantity
100 μg	4-5 weeks	$ 210.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	526.7
Formula	C32H46O6
CAS No.	87081-36-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kudo, N., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242(2), 540-547 (1998). 2. Wolff B, et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997 Feb;4(2):139-47.

Related Products

Related compounds with same targets

CRM1-IN-1 KPT330,(E)- KPT185 Verdinexor CRM1-IN-2 Selinexor (KPT-330) KPT276 LFS-1107

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Keywords

Leptomycin A 87081-36-5 Membrane transporter/Ion channel CRM1 inhibitor inhibit

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