Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays <4,000-fold selective for EP4 over other EP and prostanoid receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 280.00 | |
1 mg | 35 days | $ 530.00 | |
5 mg | 35 days | $ 2,360.00 | |
10 mg | 35 days | $ 4,170.00 |
Description | L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors. |
Targets&IC50 | EP4:0.38 nM (ki), EP4:0.6 nM (EC50) |
In vitro | L-902688 (1 μM; 24 hours; HUVE cells) treatment, decreases TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression. |
In vivo | In the monocrotaline (MCT)-induced PAH rat model, L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment decreases right ventricle fibrosis [1]. |
Molecular Weight | 419.47 |
Formula | C21H27F2N5O2 |
CAS No. | 634193-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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L-902688 634193-54-7 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor L902688 L 902688 inhibitor inhibit