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KB-130015

Catalog No. T27713 CAS 147030-48-6

KB-130015, a activator of hERG1 potassium channels, blocks native and recombinant hERG1 channels at high voltages.

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KB-130015, CAS 147030-48-6

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 970.00 $ 776.00
50 mg	6-8 weeks	$ 1,980.00 $ 1,584.00
100 mg	6-8 weeks	$ 2,500.00 $ 2,000.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

KB-130015, a activator of hERG1 potassium channels, blocks native and recombinant hERG1 channels at high voltages.

Molecular Weight	548.11
Formula	C18H14I2O4
CAS No.	147030-48-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gessner G, Macianskiene R, Starkus JG, Schönherr R, Heinemann SH. The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. Eur J Pharmacol. 2010 Apr 25;632(1-3):52-9. doi: 10.1016/j.ejphar.2010.01.010. PubMed PMID: 20097192; PubMed Central PMCID: PMC2835770. 2. Borchard R, van Bracht M, Wickenbrock I, Prull MW, Pott L, Trappe HJ. [Inhibition of the muscarinic potassium current by KB130015, a new antiarrhythmic agent to treat atrial fibrillation]. Med Klin (Munich). 2005 Nov 15;100(11):697-703. German. PubMed PMID: 16328176.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KB-130015 147030-48-6 KB 130015 KB130015 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.