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Galantide

Catalog No. T15368 CAS 138579-66-5

Galantide is a reversible and non-specific antagonist of galanin receptor.

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Galantide, CAS 138579-66-5

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Description	Galantide is a reversible and non-specific antagonist of galanin receptor.
In vitro	Galantide is also found to displace 125I-monoiodo-[TyrZ6]galanin from membranes of the insulin-producing Rin m 5F cells (IC50: <0.1 nM). Galantide dose-dependently (IC50: 1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets [1].
In vivo	Galantide ameliorates mild acute pancreatitis (AP). Galantide has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000 nM[4]. Galantide significantly reduces AP-induced hyperenzymemia by 41–49% [3]. Galanin (5 μg/rat; intracerebroventricular injection ) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 μg/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin [2].

Molecular Weight	2199.53
Formula	C104H151N25O26S
CAS No.	138579-66-5

Storage

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediatedinhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992 Jan 14;210(2):183-8. 2. Benelli A, et al. Galantide stimulates sexual behaviour in male rats. Eur J Pharmacol. 1994 Aug 1;260(2-3):279-82. 3. Barreto SG, et al. The efficacy of combining feG and galantide in mild caerulein-induced acutepancreatitis in mice. Peptides. 2010 Jun;31(6):1076-82. 4. Arletti R, et al. Galantide improves social memory in rats. Pharmacol Res. 1997 Apr;35(4):317-9.

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Keywords

Galantide 138579-66-5 Others inhibitor inhibit

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