keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 188.00 | |
5 mg | In stock | $ 560.00 | |
10 mg | In stock | $ 788.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | In stock | $ 1,660.00 | |
100 mg | In stock | $ 2,230.00 |
Description | Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). |
In vitro | Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin-stimulated production of cAMP. These agonist-like effects of galanin and Galanin Receptor Ligand M35 TFA are not additive, thus the mixed agonist/antagonist properties arise from the chimeric nature of Galanin Receptor Ligand M35 TFA acting solely at galanin receptors[1]. |
In vivo | Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task that shortened the escape latency, reduced the number of failures to reach the platform, and shortened the path length to reach the hidden platform[3]. |
Molecular Weight | 2347.62 |
Formula | C109H154N27F3O28 |
CAS No. | TP1704 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. More
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Galanin Receptor Ligand M35 TFA TP1704 GPCR/G Protein Neuroscience Neuropeptide Y Receptor Galanin Receptor Ligand M-35 TFA inhibitor inhibit