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GSK 690 Hydrochloride

Name: GSK 690 Hydrochloride
Brand: TargetMol
SKU: T11503
Rating: 4.5 (1 reviews)

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Catalog No. T11503Cas No. 2436760-79-9

GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.

GSK 690 Hydrochloride

😃Good

Catalog No. T11503Cas No. 2436760-79-9

GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.

Pack Size	Price	Availability	Quantity
100 mg	$1,450	1-2 weeks
200 mg	$1,936	1-2 weeks

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Product Introduction

Bioactivity

Description	GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.
Targets&IC50	LSD1:(kd)8 nM , LSD1:37 nM
In vitro	GSK690 (1-10 μM) synergizes with JNJ-26481585 to promote cell death across four RMS cell lines (RD, RH30, RMS13, and TE381.T cells), impacting the equilibrium of pro- and antiapoptotic proteins at 1 μM for RD cells and at 10 μM for RH30 cells. This combined treatment triggers caspase-dependent apoptosis at these same concentrations for RD and RH30 cells, respectively, and amplifies JNJ-26481585-induced G2/M phase arrest.

Chemical Properties

Molecular Weight	405.92
Formula	C₂₄H₂₄ClN₃O
Cas No.	2436760-79-9
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (307.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4635 mL	12.3177 mL	24.6354 mL	123.1770 mL
5 mM	0.4927 mL	2.4635 mL	4.9271 mL	24.6354 mL
10 mM	0.2464 mL	1.2318 mL	2.4635 mL	12.3177 mL
20 mM	0.1232 mL	0.6159 mL	1.2318 mL	6.1588 mL
50 mM	0.0493 mL	0.2464 mL	0.4927 mL	2.4635 mL
100 mM	0.0246 mL	0.1232 mL	0.2464 mL	1.2318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc