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GSK 690 Hydrochloride

Catalog No. T11503 CAS 2436760-79-9

GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.

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GSK 690 Hydrochloride Chemical Structure

GSK 690 Hydrochloride, CAS 2436760-79-9

Pack Size	Availability	Price/USD	Quantity
100 mg	10-14 weeks	$ 1,450.00
200 mg	10-14 weeks	$ 1,936.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.
Targets&IC50	LSD1:(kd)8 nM , LSD1:37 nM
In vitro	GSK690 (1-10 μM) synergizes with JNJ-26481585 to promote cell death across four RMS cell lines (RD, RH30, RMS13, and TE381.T cells), impacting the equilibrium of pro- and antiapoptotic proteins at 1 μM for RD cells and at 10 μM for RH30 cells. This combined treatment triggers caspase-dependent apoptosis at these same concentrations for RD and RH30 cells, respectively, and amplifies JNJ-26481585-induced G2/M phase arrest.

Molecular Weight	405.92
Formula	C24H24ClN3O
CAS No.	2436760-79-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (307.94 mM), Sonification is recommended.

References and Literature

1. Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. 2. Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK 690 Hydrochloride 2436760-79-9 Chromatin/Epigenetic Histone Demethylase GSK690 Hydrochloride GSK-690 Hydrochloride inhibitor inhibit

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