Powder: -20°C for 3 years
In solvent: -80°C for 2 years
GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 12-16 weeks | $ 1,577.00 | |
200 mg | 12-16 weeks | $ 1,936.00 |
Description | GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM. |
Targets&IC50 | LSD1:37 nM , LSD1:(kd)8 nM |
In vitro | GSK690 (1-10 μM) acts in concert with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells) [2]. GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest [2]. |
Molecular Weight | 405.92 |
Formula | C24H24ClN3O |
CAS No. | T11503 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (307.94 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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GSK 690 Hydrochloride T11503 Chromatin/Epigenetic Histone Demethylase Inhibitor inhibitor inhibit