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GSK 690 Hydrochloride

Catalog No. T11503 CAS T11503

GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.

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GSK 690 Hydrochloride, CAS T11503

Pack Size	Availability	Price/USD	Quantity
100 mg	12-16 weeks	$ 1,577.00
200 mg	12-16 weeks	$ 1,936.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.
Targets&IC50	LSD1:37 nM , LSD1:(kd)8 nM
In vitro	GSK690 (1-10 μM) acts in concert with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells) [2]. GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest [2].

Molecular Weight	405.92
Formula	C24H24ClN3O
CAS No.	T11503

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (307.94 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. 2. Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879.

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Keywords

GSK 690 Hydrochloride T11503 Chromatin/Epigenetic Histone Demethylase Inhibitor inhibitor inhibit

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