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Fuberidazole

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Catalog No. T19673Cas No. 3878-19-1

Fuberidazole is an antifungal agent.

Fuberidazole

Fuberidazole

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🥰Excellent
Purity: 98.95%
Catalog No. T19673Cas No. 3878-19-1
Fuberidazole is an antifungal agent.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$42In StockIn Stock
50 mg$54In StockIn Stock
100 mg$66In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.95%
Appearance:Solid
Color:Yellow
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Product Introduction

Fuberidazole AI Summary
Fuberidazole exhibits diverse bioactivities across several assays. It shows inhibition of Co2+ loaded MetAP expressed in Escherichia coli, with 10.38% inhibition at a 10 μM concentration and an IC50 value greater than 10,000 nM. At a 25 μM concentration, it inhibits Escherichia coli MetAP by 26.0% and Staphylococcus aureus MetAP by 10.0%. The compound also inhibits recombinant soluble epoxide hydrolase with an IC50 value of 207,000 nM. In human MCF7 cells, Fuberidazole inhibits VEGF production with a 15.0% inhibition rate after 24 hours and exhibits cytotoxicity with an IC50 value of 21.5 μg/mL after 48 hours as measured by the sulforhodamine B assay. It demonstrates CYP3A4 inhibition with an IC50 value greater than 10,000 nM, indicating weak inhibition, and suggests potential interactions with retinoic acid metabolism. For cytotoxicity, it has IC50 values of 105,640 nM against MCF7 cells and 102,530 nM against HepG2 cells, and at its cytotoxic IC50 concentration, it reduces VEGFR2 protein expression in MCF7 cells by 43% after 24 hours..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Fuberidazole is an antifungal agent.
Chemical Properties
Molecular Weight184.19
FormulaC11H8N2O
Cas No.3878-19-1
SmilesN1C2=CC=CC=C2N=C1C1=CC=CO1
Relative Density.1.286g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 0.07 mg/mL (0.38 mM), when pH is adjusted to 7.
DMSO: 55 mg/mL (298.6 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 5 mg/mL (27.15 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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