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Catalog No. TQ0006   CAS 180300-43-0
Synonyms: TAS-106, 3'-C-Ethynylcytidine, ECyD

Ethynylcytidine is a nucleoside antimetabolite.

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Ethynylcytidine, CAS 180300-43-0
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ethynylcytidine is a nucleoside antimetabolite.
In vitro The cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The IC50 values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. The differences in IC50 values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appears to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors.
In vivo In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with a tumor growth inhibition rate on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine on all three administration schedules. In particular, the administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor-shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.
Synonyms TAS-106, 3'-C-Ethynylcytidine, ECyD
Molecular Weight 267.24
Formula C11H13N3O5
CAS No. 180300-43-0


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 240 mg/mL (898.07 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shimamoto Y, et al. Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. Jpn J Cancer Res. 2001 Mar;92(3):343-51.

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Ethynylcytidine 180300-43-0 DNA损伤和修复 细胞周期 Nucleoside Antimetabolite/Analog 3'-C-Ethynylcytidine ECyD TAS-106 Inhibitor inhibitor inhibit