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Eledoisin

Catalog No. TP1177 CAS 69-25-0

Synonyms: Eledone peptide

Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.

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Eledoisin, CAS 69-25-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.
In vitro	Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; while this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].
In vivo	Injection of Eledoisin (0.1-1 nmol/kg) into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg).

Synonyms	Eledone peptide
Molecular Weight	1188.4
Formula	C54H85N13O15S
CAS No.	69-25-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 18.15 mg/mL (15.27 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5.

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Keywords

Eledoisin 69-25-0 GPCR/G Protein Neuroscience Neurokinin receptor inhibit Inhibitor Eledone peptide inhibitor

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