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Dithianon

Catalog No. T19285 CAS 3347-22-6

Dithianon is a broad-spectrum anthraquinone fungicide with good adhesion to the surface of leaves and fruits. Dithianon can be used to control several fungi in certain fruits and vegetables.

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Dithianon, CAS 3347-22-6

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dithianon is a broad-spectrum anthraquinone fungicide with good adhesion to the surface of leaves and fruits. Dithianon can be used to control several fungi in certain fruits and vegetables.
In vitro	When Saccharomyces cerevisiae aerobic growth index cells are treated with acute dithione, they lose cell wall and membrane integrity and die from necrosis, and this behavior is related to the reduction of protein and non-protein sulfhydryl groups. A large increase in cellular reactive oxygen species (ROS) associated with mitochondrial membrane potential modification in cells treated with Dithianon was also detected. In filamentous fungi, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells have shown that Dithianon inhibits respiration and fermentation and affects several thiol enzymes in the glycolysis pathway, such as hexokinase, phosphofructokinase, and glycoeraldeyde-3-phosphate dehydrogenase. Dithianon has cytotoxicity in vitro and affects the cell transformation activity of BLAB/c 3 T3 cells.
In vivo	The activity of testosterone hydroxylase in liver microsomes of male mice increases after acute doses of Dithianon treatment, while female mice show inactivation.

Molecular Weight	296.32
Formula	C14H4N2O2S2
CAS No.	3347-22-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Scariot FJ, et al. Necrotic cell death induced by dithianon on Saccharomyces cerevisiae. Pestic Biochem Physiol. 2018 Jul;149:137-142. 2. Halasz I, et al. Structures of four polymorphs of the pesticide dithianon solved from X-ray powder diffraction data. Acta Crystallogr B. 2012 Dec;68(Pt 6):661-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dithianon 3347-22-6 Others inhibitor inhibit

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