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Desethylamiodarone

Catalog No. T20659 CAS 83409-32-9

Synonyms: LB-33020, DAMI, N-Monodesethylamiodarone, LB 33020, N-Deethylamiodarone, LB33020

Diethylamiodarone is the main metabolite of amiodarone in vivo.

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Desethylamiodarone, CAS 83409-32-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Diethylamiodarone is the main metabolite of amiodarone in vivo.

Synonyms	LB-33020, DAMI, N-Monodesethylamiodarone, LB 33020, N-Deethylamiodarone, LB33020
Molecular Weight	617.26
Formula	C23H25I2NO3
CAS No.	83409-32-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Morvay N, Baczkó I, Sztojkov-Ivanov A, Falkay G, Papp JG, Varró A, Leprán I. Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats. Can J Physiol Pharmacol. 2015 Sep;93(9):773-7. doi: 10.1139/cjpp-2014-0530. Epub 2015 Apr 2. PubMed PMID: 26176275. 2. Khurana R, Bin Jardan YA, Wilkie J, Brocks DR. Breast milk concentrations of amiodarone, desethylamiodarone, and bisoprolol following short-term drug exposure: two case reports. J Clin Pharmacol. 2014 Jul;54(7):828-31. doi: 10.1002/jcph.272. Epub 2014 Feb 5. PubMed PMID: 24482268. 3. Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Front Pharmacol. 2016 Mar 1;7:39. doi: 10.3389/fphar.2016.00039. eCollection 2016. PubMed PMID: 26973526; PubMed Central PMCID: PMC4771766. 4. Hong LX, Ying YC, Lei Z, Chen GR. Preparation and determination of desethylamiodarone in dog lung by HPLC-MS. Pharmazie. 2011 Nov;66(11):822-5. PubMed PMID: 22204125.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Desethylamiodarone 83409-32-9 LB-33020 DAMI N-Monodesethylamiodarone LB 33020 N-Deethylamiodarone LB33020 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.