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Desethylamiodarone

Catalog No. T20659   CAS 83409-32-9
Synonyms: LB-33020, DAMI, N-Monodesethylamiodarone, LB 33020, N-Deethylamiodarone, LB33020

Diethylamiodarone is the main metabolite of amiodarone in vivo.

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Desethylamiodarone, CAS 83409-32-9
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diethylamiodarone is the main metabolite of amiodarone in vivo.
Synonyms LB-33020, DAMI, N-Monodesethylamiodarone, LB 33020, N-Deethylamiodarone, LB33020
Molecular Weight 617.26
Formula C23H25I2NO3
CAS No. 83409-32-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Morvay N, Baczkó I, Sztojkov-Ivanov A, Falkay G, Papp JG, Varró A, Leprán I. Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats. Can J Physiol Pharmacol. 2015 Sep;93(9):773-7. doi: 10.1139/cjpp-2014-0530. Epub 2015 Apr 2. PubMed PMID: 26176275. 2. Khurana R, Bin Jardan YA, Wilkie J, Brocks DR. Breast milk concentrations of amiodarone, desethylamiodarone, and bisoprolol following short-term drug exposure: two case reports. J Clin Pharmacol. 2014 Jul;54(7):828-31. doi: 10.1002/jcph.272. Epub 2014 Feb 5. PubMed PMID: 24482268. 3. Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Front Pharmacol. 2016 Mar 1;7:39. doi: 10.3389/fphar.2016.00039. eCollection 2016. PubMed PMID: 26973526; PubMed Central PMCID: PMC4771766. 4. Hong LX, Ying YC, Lei Z, Chen GR. Preparation and determination of desethylamiodarone in dog lung by HPLC-MS. Pharmazie. 2011 Nov;66(11):822-5. PubMed PMID: 22204125.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Desethylamiodarone 83409-32-9 LB-33020 DAMI N-Monodesethylamiodarone LB 33020 N-Deethylamiodarone LB33020 inhibitor inhibit