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Deacetyldiltiazem

Catalog No. T21008 CAS 42399-40-6

Synonyms: Desacetyl Diltiazem

Deacetyldiltiazem is a metabolite product of Diltiazem which is a coronary vasodilator, and is present in the plasma of individuals taking Diltiazem.

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Deacetyldiltiazem, CAS 42399-40-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Deacetyldiltiazem is a metabolite product of Diltiazem which is a coronary vasodilator, and is present in the plasma of individuals taking Diltiazem.

Synonyms	Desacetyl Diltiazem
Molecular Weight	372.48
Formula	C20H24N2O3S
CAS No.	42399-40-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Kurokawa T, Fukami T, Nakajima M. Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase. Drug Metab Dispos. 2015 Aug;43(8):1218-25. doi: 10.1124/dmd.115.064089. Epub 2015 May 15. PubMed PMID: 25979260. 2. Qiang F, Kang KW, Han HK. Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats. Biopharm Drug Dispos. 2012 Nov;33(8):446-54. doi: 10.1002/bdd.1811. Epub 2012 Sep 18. PubMed PMID: 22927137. 3. Choi DH, Choi JS, Li C, Choi JS. Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin. Pharmacol Rep. 2011;63(6):1574-82. PubMed PMID: 22358108. 4. Hong SP, Yang JS, Han JY, Ha SI, Chung JW, Koh YY, Chang KS, Choi DH. Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin. J Pharm Pharmacol. 2011 Jan;63(1):129-35. PubMed PMID: 21189658.

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Keywords

Deacetyldiltiazem 42399-40-6 Desacetyl Diltiazem inhibitor inhibit

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