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Damnacanthal

Catalog No. TN1549 CAS 477-84-9

Synonyms: 丹宁卡

Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.

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Damnacanthal, CAS 477-84-9

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Purity: 98%

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Description	Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.
Targets&IC50	phosphorylation of exogenous substrates by p56lck:220 nM (IC50), p56lckautophosphorylation:46 nM (IC50)
In vitro	Here we show that Damnacanthal has profound inhibitory activity on mast cell activation through this pathway. The release of the granule compounds beta-hexosaminidase and tryptase release was completely abrogated by Damnacanthal at doses that were non-toxic to mast cells. In addition, Damnacanthal inhibited activation-dependent pro-inflammatory gene induction, as well as cytokine/chemokine release in response to mast cell stimulation. The mechanism underlying Damnacanthal inhibition was linked to impaired phosphorylation of Syk and Akt. Furthermore, Damnacanthal inhibited mast cell activation in response to calcium ionophore A23187[1]

Synonyms	丹宁卡
Molecular Weight	282.25
Formula	C16H10O5
CAS No.	477-84-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Damnacanthal inhibits IgE receptor-mediated activation of mast cells.Mol Immunol. 2015 May;65(1):86-93.

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Keywords

Damnacanthal 477-84-9 PI3K/Akt/mTOR信号通路蛋白酪氨酸激酶免疫与炎症细胞骨架血管生成 IL Receptor Akt Syk Inhibitor inhibitor inhibit

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