Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 5 days | $ 390.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 456.00 |
Description | Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). |
Targets&IC50 | FD:0.006 μM, MAC:0.05 μM |
In vitro | Complement factor D-IN-1 displays similar potency against human and monkey FD (IC50s: 0.005 μM in FD thioesterolytic assays and 0.011 μM in 50% serum MAC deposition assays for both human and monkey) [1]. |
In vivo | Complement factor D-IN-1 shows an excellent oral PK profile in Sprague–Dawley rats and, following an oral dose (10 mg/kg) in Brown Norway rats, demonstrates a good distribution and sustained exposure in ocular tissues including the neural retina. Mean exposure levels in plasma, the PEC, and the retina at 6 h after dosing are 0.36, 0.43, and 0.09 μM, respectively [1]. |
Molecular Weight | 483.32 |
Formula | C21H19BrN6O3 |
CAS No. | 1386455-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (517.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Complement factor D-IN-1 1386455-76-0 Others Complement factor D IN 1 Complement factor DIN1 inhibitor inhibit