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Cipargamin

Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.

Catalog No. T16326Cas No. 1193314-23-6

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Purity:98.58%

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COA HPLC HNMR

Cipargamin

Catalog No. T16326Cas No. 1193314-23-6

Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.

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Pack Size	Price	Availability
1 mg	$53	In Stock
2 mg	$76	In Stock
5 mg	$142	In Stock
10 mg	$228	In Stock
25 mg	$438	In Stock
50 mg	$743	In Stock
100 mg	$1,190	In Stock
200 mg	$1,580	In Stock
500 mg	$2,380	In Stock
1 mL x 10 mM (in DMSO)	$157	In Stock

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Product Introduction

Bioactivity

Description	Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.
Targets&IC50	P. falciparum:1 nM
In vitro	Cipargamin is the most effective inhibitor of early gametocyte development at 50 and 500 nM. Cipargamin displays a dose-dependent inhibiting effect on late gametocyte development. Cipargamin inhibits T. gondii with an MIC90 for tachyzoites of 5 μM and an MIC50 of 1 μM. At the highest concentration tested (10 μM), It has no toxicity to human foreskin fibroblasts (HFFs). Cipargamin shows effective activities against a panel of culture-adapted P. falciparum strains (IC50: 0.5-1.4 nM). Cipargamin is effective as an artesunate with potency in the low nanomolar range (ICIC50 values consistently <10 nM) against all P. falciparum and P. vivax isolates [1][2][3].
In vivo	Cipargamin (100 mg/kg) fully clears P. berghei infection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg. Cipargamin displays favorable pharmacokinetic properties and shows single-dose cure efficacy in a malaria mouse model [3].
Alias	KAE609, NITD609

Chemical Properties

Molecular Weight	390.24
Formula	C₁₉H₁₄Cl₂FN₃O
Cas No.	1193314-23-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 55 mg/mL (140.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5625 mL	12.8126 mL	25.6253 mL	128.1263 mL
5 mM	0.5125 mL	2.5625 mL	5.1251 mL	25.6253 mL
10 mM	0.2563 mL	1.2813 mL	2.5625 mL	12.8126 mL
20 mM	0.1281 mL	0.6406 mL	1.2813 mL	6.4063 mL
50 mM	0.0513 mL	0.2563 mL	0.5125 mL	2.5625 mL
100 mM	0.0256 mL	0.1281 mL	0.2563 mL	1.2813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc