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Cipargamin

Catalog No. T16326 CAS 1193314-23-6

Synonyms: KAE609, NITD609

Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.

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Cipargamin, CAS 1193314-23-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 53.00
2 mg	In stock	$ 76.00
5 mg	In stock	$ 142.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 438.00
50 mg	In stock	$ 743.00
100 mg	In stock	$ 1,190.00
200 mg	In stock	$ 1,580.00
500 mg	In stock	$ 2,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 157.00

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Purity: 98.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.
Targets&IC50	P. falciparum:1 nM
In vitro	Cipargamin is the most effective inhibitor of early gametocyte development at 50 and 500 nM. Cipargamin displays a dose-dependent inhibiting effect on late gametocyte development. Cipargamin inhibits T. gondii with an MIC90 for tachyzoites of 5 μM and an MIC50 of 1 μM. At the highest concentration tested (10 μM), It has no toxicity to human foreskin fibroblasts (HFFs). Cipargamin shows effective activities against a panel of culture-adapted P. falciparum strains (IC50: 0.5-1.4 nM). Cipargamin is effective as an artesunate with potency in the low nanomolar range (ICIC50 values consistently <10 nM) against all P. falciparum and P. vivax isolates [1][2][3].
In vivo	Cipargamin (100 mg/kg) fully clears P. berghei infection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg. Cipargamin displays favorable pharmacokinetic properties and shows single-dose cure efficacy in a malaria mouse model [3].

Synonyms	KAE609, NITD609
Molecular Weight	390.24
Formula	C19H14Cl2FN3O
CAS No.	1193314-23-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 55 mg/mL (140.94 mM), Sonication is recommended.

References and Literature

1. Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92. 2. van Pelt-Koops JC, et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. 3. Rottmann M, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Drug Repurposing Compound Library Pediatric Drug Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library Clinical Compound Library Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cipargamin 1193314-23-6 Microbiology/Virology Parasite inhibit KAE609 KAE-609 NITD-609 NITD 609 Inhibitor NITD609 KAE 609 inhibitor

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