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Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $99 | In Stock | In Stock |
| Description | Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation. |
| In vitro | In HaCat and JB6 cells, Cephradine monohydrate (0.5, 1, and 2 mM, 2, 4, 6, and 12 hours) inhibited SUV-induced phosphorylation of p38, JNKs, and H2AX in a dose- and time-dependent manner, and suppressed the secretion of IL6 and TNF-α. [2] |
| In vivo | Methods: The dorsal skin of adult Babl/c mice was topically applied with Cephradine monohydrate (100 mg/kg), followed by SUV (100 KJ/m²) irradiation to investigate the effect of Cephradine monohydrate on SUV-induced skin inflammation in mice. Results: Cephradine monohydrate treatment significantly reduced the increase in epidermal thickness and immune cell infiltration in mouse skin after SUV (100 KJ/m²) irradiation. It also effectively inhibited the phosphorylation of p38, JNKs, and H2AX, as well as the secretion of IL-6 and TNF-α.[2] |
| Synonyms | Cefradine monohydrate |
| Molecular Weight | 367.42 |
| Formula | C16H21N3O5S |
| Cas No. | 75975-70-1 |
| Smiles | O=C1N2[C@@]([C@@H]1NC([C@H](N)C=3CC=CCC3)=O)(SCC(C)=C2C(O)=O)[H].O |
| Relative Density. | 1.31g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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