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Cephradine monohydrate

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Catalog No. T14929Cas No. 75975-70-1
Alias Cefradine monohydrate

Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation.

Cephradine monohydrate

Cephradine monohydrate

🥰Excellent
Purity: 99.91%
Catalog No. T14929Alias Cefradine monohydrateCas No. 75975-70-1
Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation.
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25 mg$99In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.91%
Appearance:Solid
Color:Yellow
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Product Introduction

Bioactivity
Description
Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation.
In vitro
In HaCat and JB6 cells, Cephradine monohydrate (0.5, 1, and 2 mM, 2, 4, 6, and 12 hours) inhibited SUV-induced phosphorylation of p38, JNKs, and H2AX in a dose- and time-dependent manner, and suppressed the secretion of IL6 and TNF-α. [2]
In vivo
Methods: The dorsal skin of adult Babl/c mice was topically applied with Cephradine monohydrate (100 mg/kg), followed by SUV (100 KJ/m²) irradiation to investigate the effect of Cephradine monohydrate on SUV-induced skin inflammation in mice.
Results: Cephradine monohydrate treatment significantly reduced the increase in epidermal thickness and immune cell infiltration in mouse skin after SUV (100 KJ/m²) irradiation. It also effectively inhibited the phosphorylation of p38, JNKs, and H2AX, as well as the secretion of IL-6 and TNF-α.[2]
SynonymsCefradine monohydrate
Chemical Properties
Molecular Weight367.42
FormulaC16H21N3O5S
Cas No.75975-70-1
SmilesO=C1N2[C@@]([C@@H]1NC([C@H](N)C=3CC=CCC3)=O)(SCC(C)=C2C(O)=O)[H].O
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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