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Camstatin acetate

Catalog No. TP2057L

Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calmodulin-binding IQ motif of PEP-19.

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Camstatin acetate, CAS N/A

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Purity: 98%

Biological Description

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Description

Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calmodulin-binding IQ motif of PEP-19.

In vitro

A truncated Camstatin acetate-in which the IQ motif serine is the only phosphorylatable residue-was screened against 42 different kinases. Truncated Camstatin acetate is selectively phosphorylated by four isoforms of protein kinase C. Treatment of full-length PEP-19 with PKCgamma catalyzes phosphorylation of the same serine residue. Phosphorylation of Camstatin acetate inhibits its binding to calmodulin. Both Camstatin acetate and phospho-Camstatin acetate exist in similar dynamic turn-like conformations[1].

Molecular Weight	2820.21
Formula	C124H207N39O36

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. J Bradley Dickerson, et al. The influence of phosphorylation on the activity and structure of the neuronal IQ motif protein, PEP-19. Brain Res. 2006 May 30;1092(1):16-27.

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Keywords

Camstatin acetate 免疫与炎症 NO Synthase Inhibitor inhibitor inhibit

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