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CP-339818

Catalog No. T31050 CAS 185855-91-8

Synonyms: CP-339818 HCl, CP 339818, CP339818HCl

CP-339818 is of great value in immune system studies, where the loss of Kv1.4 makes it functionally selective to Kv1.3, and it has shown inhibition of T cell activation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CP-339818, CAS 185855-91-8

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 970.00 $ 776.00
50 mg	6-8 weeks	$ 1,980.00 $ 1,584.00
100 mg	6-8 weeks	$ 2,500.00 $ 2,000.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

CP-339818 is of great value in immune system studies, where the loss of Kv1.4 makes it functionally selective to Kv1.3, and it has shown inhibition of T cell activation.

Synonyms	CP-339818 HCl, CP 339818, CP339818HCl
Molecular Weight	304.437
Formula	C21H24N2
CAS No.	185855-91-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sforna L, D'Adamo MC, Servettini I, Guglielmi L, Pessia M, Franciolini F, Catacuzzeno L. Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia. J Neurophysiol. 2015 Apr 1;113(7):2653-65. doi: 10.1152/jn.00379.2014. PubMed PMID: 25652918; PubMed Central PMCID: PMC4416569. 2. Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588(Pt 18):3525-37. doi: 10.1113/jphysiol.2010.190207. PubMed PMID: 20643768; PubMed Central PMCID: PMC2988516. 3. Lee YT, Vasilyev DV, Shan QJ, Dunlop J, Mayer S, Bowlby MR. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. PubMed PMID: 18162181. 4. Jäger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301. PubMed PMID: 9490854; PubMed Central PMCID: PMC2230732.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CP-339818 185855-91-8 CP-339818 HCl CP339818 CP 339818 CP339818HCl inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.