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CHF5407

Catalog No. T13992 CAS 1004312-94-0

Synonyms: SVT-47060

CHF5407（SVT-47060） is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.CHF5407 has an effect on bronchospasm and may be used in the study of respiratory disorders.CHF5407 is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.

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CHF5407, CAS 1004312-94-0

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 100%

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Description	CHF5407（SVT-47060） is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.CHF5407 has an effect on bronchospasm and may be used in the study of respiratory disorders.CHF5407 is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.
In vitro	Producing a potent (pIC50=9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol in the guinea pig isolated trachea and human isolated bronchus, CHF5407 exhibits a very slow dissociation from M3 receptors (hM3; t1/2=166 min) and markedly short-acting effects at M2 receptors (hM2; t1/2=31 min)[1].
In vivo	Administered intratracheally in a single dose of 100 μl at doses of 0.1, 0.3, and 1 nmol/kg, CHF5407 exerted a dose-dependent and potent inhibition of ACh-induced bronchospasm (20 g/kg; i.v.) in guinea pigs (450-550 g), with an ED50 value of 0.15 nmol/kg[1].

Synonyms	SVT-47060
Molecular Weight	613.46
Formula	C27H25BrF4N2O3S
CAS No.	1004312-94-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Villetti G, et al. Bronchodilator activity of(3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407),a potent,long-acting, and selective muscarinic M3 receptor antagonist. J Pharmacol Exp Ther. 2010 Dec;335(3):622-35.

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Keywords

CHF5407 1004312-94-0 Neuroscience AChR CHF 5407 CHF-5407 SVT-47060 inhibitor inhibit

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