Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).
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Description | CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM). |
Targets&IC50 | Topo I:2.3 μM |
In vitro | CH0793076 (6 days at 37°C) displays antiproliferative activity against PC-6/BCRP and PC-6/pRC cells (IC50: 0.35 and 0.18 nM). |
In vivo | TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses) shows more than 50% of tumor growth inhibition in all nine models. |
Synonyms | TP3076 |
Molecular Weight | 458.51 |
Formula | C26H26N4O4 |
CAS No. | 534605-78-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CH-0793076 534605-78-2 DNA Damage/DNA Repair Topoisomerase TP3076 TP 3076 CH 0793076 TP-3076 CH0793076 inhibitor inhibit