Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 265.00 | |
5 mg | 35 days | $ 1,160.00 | |
10 mg | 35 days | $ 1,980.00 |
Description | CC-401 is a specific inhibitor of JNK (Ki: 25-50nM). |
Targets&IC50 | JNK:25-50 nM (Ki) |
In vitro | CC-401 is a second-generation ATP-competitive inhibitor of all three forms of JNK. It is selective against JNK over other kinases such as p38, ERK, IKK2, and ZAP70. CC-401 potently inhibits JNK in cell-based assay with a concentration of 1 to 5μM. The activation of JNK signaling is identified in many immune-mediated kidney disease models. Thus, as the JNK inhibitor, CC-401 is found to be effective in these renal injury models. In the acute anti-GBM disease, CC-401 inhibits JNK activation and causes a 50%-70% reduction of proteinuria. In addition, CC-401 is also used in liver injury models [1][2][3]. |
Molecular Weight | 388.47 |
Formula | C22H24N6O |
CAS No. | 395104-30-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥19.4mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CC-401 395104-30-0 Others CC401 CC 401 inhibitor inhibit