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Biotin-PEG12-NHS ester

Name: Biotin-PEG12-NHS ester
Brand: TargetMol
SKU: T17561
Rating: 4.5 (1 reviews)

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Catalog No. T17561Cas No. 1934296-88-4

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.

Biotin-PEG12-NHS ester

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Purity: 98.00%

Catalog No. T17561Cas No. 1934296-88-4

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.

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Batch Information

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Purity:98.00%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.
In vitro	PROTACs consist of two ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to the target protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	941.09
Formula	C₄₁H₇₂N₄O₁₈S
Cas No.	1934296-88-4
Smiles	C(CCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (106.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0626 mL	5.3130 mL	10.6260 mL	53.1299 mL
5 mM	0.2125 mL	1.0626 mL	2.1252 mL	10.6260 mL
10 mM	0.1063 mL	0.5313 mL	1.0626 mL	5.3130 mL
20 mM	0.0531 mL	0.2656 mL	0.5313 mL	2.6565 mL
50 mM	0.0213 mL	0.1063 mL	0.2125 mL	1.0626 mL
100 mM	0.0106 mL	0.0531 mL	0.1063 mL	0.5313 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc