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BN-82685

Catalog No. T25167 CAS 477603-18-2

BN-82685 is an inhibitor of quinone-based CDC25 that is active in vitro and in vivo, which indicates the interest of the inhibition of CDC25 enzymes as an anticancer therapeutic strategy.

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BN-82685, CAS 477603-18-2

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

BN-82685 is an inhibitor of quinone-based CDC25 that is active in vitro and in vivo, which indicates the interest of the inhibition of CDC25 enzymes as an anticancer therapeutic strategy.

Molecular Weight	265.33
Formula	C12H15N3O2S
CAS No.	477603-18-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Berg MG, Wan L, Younis I, Diem MD, Soo M, Wang C, Dreyfuss G. A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Mol Cell Biol. 2012 Apr;32(7):1271-83. doi: 10.1128/MCB.05788-11. Epub 2012 Jan 17. PubMed PMID: 22252314; PubMed Central PMCID: PMC3302438. 2. Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol. 2006 Apr;18(2):185-91. Epub 2006 Feb 17. Review. PubMed PMID: 16488126. 3. Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H. CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples. J Neurooncol. 2010 Oct;100(1):43-9. doi: 10.1007/s11060-010-0147-3. Epub 2010 Mar 10. PubMed PMID: 20217459. 4. Cazales M, Boutros R, Brezak MC, Chaumeron S, Prevost G, Ducommun B. Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly. Mol Cancer Ther. 2007 Jan;6(1):318-25. PubMed PMID: 17237290.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BN-82685 477603-18-2 BN82685 BN 82685 inhibitor inhibit

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