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BMY-27709

Catalog No. T26873 CAS 99390-76-8

Synonyms: BMY 27709, BMY27709

BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses.BMY-27709 acts early in the course of H1 and H2 virus infections, and exhibits antiviral activity through inhibition of hemagglutinin proteins. However, BMY-27709 has no effect on H3 subtype viruses and influenza B/Lee/40 viruses.

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BMY-27709, CAS 99390-76-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

Purity: 98.07%

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Description

In vitro

BMY-27709 has an IC50 of 3-8 microM for a WSN 33 virus growth in a multicycle replication assay and is active against all H1 and H2 subtype viruses tested. However, BMY-27709 was found to be inactive against H3 subtype viruses, as well as influenza B/Lee/40 virus. BMY-27709 was also found to act against H1 and H2 viruses early in infection, suggesting that the target for inhibition is the hemagglutinin protein. This was confirmed through the use of reassortant viruses and the isolation of a virus resistant to BMY-27709. The resistant virus isolated contained phenylalanine to serine change at amino acid 110 of the HA2 subunit. That this single mutation was responsible for the acquisition of resistance to BMY-27709 was proven through reverse genetics, as a transfectant virus containing only this change was shown to be resistant to BMY-27709, while the control virus without this mutation remained sensitive. BMY-27709 is able to inhibit virus-induced red blood cell hemolysis, suggesting that it blocks the membrane fusion function of hemagglutinin. These experiments further illustrate that the hemagglutinin protein of the influenza virus is a viable target for the discovery and development of small-molecule inhibitors of virus growth.[1]

Synonyms	BMY 27709, BMY27709
Molecular Weight	337.84
Formula	C17H24ClN3O2
CAS No.	99390-76-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Luo G, et al. Characterization of a hemagglutinin-specific inhibitor of influenza A virus. Virology. 1996;226(1):66-76. 2. Luo G, et al. Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus. J Virol. 1997;71(5):4062-4070. 3. Combrink KD, et al. Salicylamide inhibitors of influenza virus fusion. Bioorg Med Chem Lett. 2000;10(15):1649-1652. 4. Hsieh HP, et al. Strategies of development of antiviral agents directed against influenza virus replication. Curr Pharm Des. 2007;13(34):3531-3542.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Viral Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

BMY-27709 99390-76-8 Microbiology/Virology Influenza Virus BMY 27709 BMY27709 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.