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BMS-214662

Catalog No. T10567 CAS 195987-41-8

BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem cells/progenitors, and has the ability to selectively target CML stem cells/progenitors with antitumor activity.

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BMS-214662, CAS 195987-41-8

Pack Size	Availability	Price/USD
5 mg	Synthesizing,6-8 weeks	$ 1,070.00
50 mg	Synthesizing,6-8 weeks	$ 2,180.00
100 mg	Synthesizing,6-8 weeks	$ 2,800.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem cells/progenitors, and has the ability to selectively target CML stem cells/progenitors with antitumor activity.
Targets&IC50	K-Ras:2.3 μM , Ras-CVLL:1.3 μM , farnesyl transferase:1.35 nM

Molecular Weight	489.61
Formula	C25H23N5O2S2
CAS No.	195987-41-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (204.24 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hunt JT, et al. Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. J Med Chem. 2000 Oct 5;43(20):3587-95. 2. Rose WC, et al. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 2001 Oct 15;61(20):7507-17.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-214662 195987-41-8 MAPK Raf BMS214662 BMS 214662 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.