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Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

Catalog No. T14441 CAS 1421933-29-0

Synonyms: azido-peg4-amido-tri-t-butoxycarbonylethoxymethyl-methane

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is employed for PROTAC synthesis[1].

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Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, CAS 1421933-29-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is employed for PROTAC synthesis[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Synonyms	azido-peg4-amido-tri-t-butoxycarbonylethoxymethyl-methane
Molecular Weight	778.93
Formula	C36H66N4O14
CAS No.	1421933-29-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

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