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Atezolizumab

Catalog No. T9902 CAS 1380723-44-3

Synonyms: Atezolizumab (anti-PD-L1), anti-PD-L1, MPDL3280A

Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Atezolizumab, CAS 1380723-44-3

Pack Size	Availability	Price/USD
1 mg	In stock	229.00
5 mg	In stock	544.00
25 mg	In stock	2070.00
50 mg	In stock	3307.00

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Purity 99.1%

COA

Purity 60mg/ml

COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.
Targets&IC50	hPD-L1
Cell Research	Objective: Determine the binding of [111In]PD-L1-mAb to tumor cell lines Cells: NCI-H2444（Lung Cancer cell line）, MDAMB231（Breast Cancer cell line）,etc Concentrations: 1 μCi/100μl Incubation Time: 1 h Method: Incubating 1 μCi of [111In]PD-L1-mAb with 1×106cells (in triplicate for each cell line) for 1h at 37°C. PD-L1 blocking was performed by adding a 10-fold molar equivalent excess of the non-labeled mAb. After incubation, cells were washed three times with cold PBS prior to counting on an automated gamma counter. Cell lines: NCI-H2444（Lung Cancer cell line）, MDAMB231（Breast Cancer cell line）,etc
Animal Research	Objective: Developed and evaluated radiolabeled [111In] PD-L1-mAb and near-infrared dye conjugated NIR-PD-L1-mAb (Atezolizumab) for non-invasive imaging of PD-L1 expression in tumors Animal Models: NSG mice (humanized mice) were implanted subcutaneously with CHO-PDL1, CHO, H2444 H1155 cells and orthotopically in the upper mammary fat pads with MDAMB231 and SUM149 cells Formulation: 14.8 MBq (400 μCi) of [111In]PD-L1-mAb or 22 μg of NIR-PD-L1-mAb

Synonyms	Atezolizumab (anti-PD-L1) , anti-PD-L1 , MPDL3280A
Purity	99.1%
Molecular Weight	145000
CAS No.	1380723-44-3

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Inman BA, et al. Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer. Clin Cancer Res. 2017 Apr 15;23(8):1886-1890. 2. Deng R, et al. Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. MAbs. 2016;8(3):593-603. 3. Zheng Y, et al. Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer. Bioengineered. 2017 Jul 4;8(4):367-373. 4. Herbst RS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014 Nov 27;515(7528):563-7.

Related Products

Related compounds with same targets

Pembrolizumab Nivolumab Avelumab Atezolizumab PDL-1 cpd 10 BMS-1001 Phellodendrine chloride BMS-1166

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