Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw
Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | 229.00 | |
5 mg | In stock | 544.00 | |
25 mg | In stock | 2070.00 | |
50 mg | In stock | 3307.00 |
Description | Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1. |
Targets&IC50 | hPD-L1 |
Cell Research |
Objective: Determine the binding of [111In]PD-L1-mAb to tumor cell lines
Cells: NCI-H2444(Lung Cancer cell line), MDAMB231(Breast Cancer cell line),etc
Concentrations: 1 μCi/100μl
Incubation Time: 1 h
Method: Incubating 1 μCi of [111In]PD-L1-mAb with 1×106cells (in triplicate for each cell line) for 1h at 37°C. PD-L1 blocking was performed by adding a 10-fold molar equivalent excess of the non-labeled mAb. After incubation, cells were washed three times with cold PBS prior to counting on an automated gamma counter.
Cell lines: NCI-H2444(Lung Cancer cell line), MDAMB231(Breast Cancer cell line),etc
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Animal Research |
Objective: Developed and evaluated radiolabeled [111In] PD-L1-mAb and near-infrared dye conjugated NIR-PD-L1-mAb (Atezolizumab) for non-invasive imaging of PD-L1 expression in tumors
Animal Models: NSG mice (humanized mice) were implanted subcutaneously with CHO-PDL1, CHO, H2444 H1155 cells and orthotopically in the upper mammary fat pads with MDAMB231 and SUM149 cells
Formulation: 14.8 MBq (400 μCi) of [111In]PD-L1-mAb or 22 μg of NIR-PD-L1-mAb
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Synonyms | Atezolizumab (anti-PD-L1) , anti-PD-L1 , MPDL3280A |
Purity | 99.1% |
Molecular Weight | 145000 |
CAS No. | 1380723-44-3 |
Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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