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Aldoxorubicin

Name: Aldoxorubicin
Brand: TargetMol
SKU: T11090L
Rating: 4.5 (1 reviews)

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Catalog No. T11090LCas No. 1361644-26-9

Alias INNO-206, DOXO-EMCH

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

Aldoxorubicin

😃Good

Catalog No. T11090LAlias INNO-206, DOXO-EMCHCas No. 1361644-26-9

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
In vitro	Aldoxorubicin (0.27 to 2.16 μM) suppresses blood vessel formation. Aldoxorubicin (0.27 to 2.16 μM) also reduces multiple myeloma cell growth in a pH-dependent fashion.
In vivo	Aldoxorubicin displays a good safety profile at doses up to 260 mg/mL doxorubicin equivalents and is able to cause tumor regressions in breast cancer, small cell lung cancer, and sarcoma in phase I study[2]. In a murine renal cell carcinoma model and in breast carcinoma xenograft models, Aldoxorubicin also shows superior activity over doxorubicin [3]. On days 28, Aldoxorubicin (10.8 mg/kg, i.v.) displays obviously smaller tumor volumes and IgG levels, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1].
Synonyms	INNO-206, DOXO-EMCH

Chemical Properties

Molecular Weight	750.75
Formula	C₃₇H₄₂N₄O₁₃
Cas No.	1361644-26-9
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (99.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.4 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3320 mL	6.6600 mL	13.3200 mL	66.6001 mL
5 mM	0.2664 mL	1.3320 mL	2.6640 mL	13.3200 mL
10 mM	0.1332 mL	0.6660 mL	1.3320 mL	6.6600 mL
20 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3300 mL
50 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc